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北京索萊寶科技有限公司
產(chǎn)品展廳
Anti-E2F5 Polyclonal Antibody
  • 品牌:Solarbio
  • 產(chǎn)地:北京
  • 貨號:K107154P
  • 發(fā)布日期: 2019-05-13
  • 更新日期: 2025-07-17
產(chǎn)品詳請
產(chǎn)地 北京
品牌 Solarbio
保存條件 Store at -20°C. Avoid freeze / thaw cycles.
貨號 K107154P
應(yīng)用范圍 WB IHC
CAS編號
抗體名 Anti-E2F5 Polyclonal Antibody
克隆性 Polyclonal Antibody
靶點
適應(yīng)物種 Human Mouse Rat
形態(tài)
宿主 Rabbit
亞型 IgG
標識物 E2F-5;transcription factor E2F5
濃度 %
免疫原 A synthetic peptide of human E2F5
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms.
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