Anti-USP8 Polyclonal Antibody
- 發(fā)布日期： 2019-05-13
- 更新日期： 2025-07-17
產(chǎn)品詳請
| 產(chǎn)地 |
北京
|
| 品牌 |
Solarbio
|
| 保存條件 |
Store at -20°C. Avoid freeze / thaw cycles.
|
| 貨號 |
K106918P
|
| 應用范圍 |
WB IHC
|
| CAS編號 |
|
| 抗體名 |
Anti-USP8 Polyclonal Antibody
|
| 克隆性 |
Polyclonal Antibody
|
| 靶點 |
|
| 適應物種 |
Human
|
| 形態(tài) |
|
| 宿主 |
Rabbit
|
| 亞型 |
IgG
|
| 標識物 |
KIAA0055;UBPY;hUBPy;Ubiquitin thioesterase 8
|
| 濃度 |
%
|
| 免疫原 |
A synthetic peptide of human USP8
|
Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability.
